Systemic inflammatory response unleashed by sepsis or induced by a sterile endogenous insult, is a key phenomenon that often characterize the critically ill patient admitted to an intensive care unit. This includes a wide range of aetiologies; abdominal sepsis, toxicities related to haematologic treatment of patients, thrombo-ischemic events, and acute respiratory distress syndrome (ARDS) featured by complex pathophysiology involving the inflammatory cascade, lung mechanics, and systemic and pulmonary circulation.

This project aims to characterize inflammatory patterns and trajectories for different disease conditions or subgroups in heterogenous syndromes as ARDS. Furthermore, to reveal inflammatory targets that are promising for biomedical intervention.