Comprehensive Review on Complement
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
by Peter Garred, Andrea Tenner and Tom Eirik Mollnes
In this up-to-date and comprehensive review published open-access in the prestigious journal Pharmacological Reviews (IF 18.9) the authors cover the main aspects of the complement system, from the physiological functions, through the pathogenesis of deficiencies and mutations, to forming a platform for future discussions of the complex and variable pathophysiology of a number of diseases. All is wrapped up with discussion of the various therapeutic approaches for different complement-driven disease conditions. This review intends to give an understanding of the complement system for those who are not in the field, as well as an update for the complementologists at all stages of training.