Novel mechanism of selective C3 activation by air bubbles

Benjamin S. Storm and collaborators in J Immunology

 

A breaking news paper was released on PubMed November 3rd published in the highly distinguished Journal of Immunology. Benjamin (photo) and colleagues here document a novel mechanism of selective activation of C3 with minor activation of the terminal complement pathway in a whole blood model bubbled with air. The findings might have important implications for treatment of patients with the serious condition “venous air embolism”.

Congratulations to Benjamin and all collaborators. Here is the link to the paper:

Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood.Storm BS, Christiansen D, Fure H, Ludviksen JK, Lau C, Lambris JD, Woodruff TM, Brekke OL, Braaten T, Nielsen EW, Mollnes TE.J Immunol. 2021 Nov 3:ji2100308. doi: 10.4049/jimmunol.2100308. Online ahead of print.PMID: 34732467

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