The dual role of complement and CD14 in inflammation

Principal investigator(s):

Description

Since the «dual-inhibition» of complement (C3, C5) and TLRs (the co-receptor CD14, acting with TLR4, TLR2 and others) was postulated, Mollnes and the NCRG have in a number of papers showed that the combination of inhibition has attenuated the inflammatory reaction substantial more than either of them. This has been the case in both non-sterile and in sterile conditions. Thus, a main aim for the NCRG is to continue the work on this “dual inhibition”.

Participants

All members of the NCRG