The dual role of complement and CD14 in inflammation

Principal investigator(s):

Description

Since the «dual-inhibition» of complement (C3, C5) and TLRs (the co-receptor CD14, acting with TLR4, TLR2 and others) was postulated, Mollnes and the NCRG have in a number of papers showed that the combination of inhibition has attenuated the inflammatory reaction substantial more than either of them. This has been the case in both non-sterile and in sterile conditions. Thus, a main aim for the NCRG is to continue the work on this “dual inhibition”.

Participants

All members of the NCRG

Participants

Ludviksen, Judith A.K. Medical laboratory technologist
Renathe H. Grønli Medical laboratory technologist