The dual role of complement and CD14 in inflammation

Principal investigator(s):

Description

Since the «dual-inhibition» of complement (C3, C5) and TLRs (the co-receptor CD14, acting with TLR4, TLR2 and others) was postulated, Mollnes and the NCRG have in a number of papers showed that the combination of inhibition has attenuated the inflammatory reaction substantial more than either of them. This has been the case in both non-sterile and in sterile conditions. Thus, a main aim for the NCRG is to continue the work on this “dual inhibition”.

 

Participants

Grønli, Renathe H. Medical laboratory technologist
Brekke, Ole-Lars Professor/Senior Consultant/Deputy Bodø
Lau, Corinna Researcher
Pettersen, Kristin Medical laboratory technologist
Pischke, Søren Professor/Senior Consultant Deputy Oslo
Schjalm, Camilla Chief medical laboratory technologist
Barratt-Due, Andreas Senior Researcher/Senior Consultant
Emblem, Åse Chief medical laboratory technologist
Nilsson, Per H. Senior Researcher/NCRG Secretary
Roscher, Elin PhD student
Storm, Benjamin S. Ass. professor Senior Consultant
Berg, Ingvild Johanna Medical laboratory technologist
Mollnes, Tom Eirik Professor at University of Oslo
Prytz, Audhild PhD student
McAdam Ekholt, Karin Medical laboratory technologist
Dahl, Tuva B. Researcher