Transplantation

Principal investigator(s):

Description

Transplantation represents localised ischemia/reperfusion injury to the transplanted organ, which triggers the whole immune system and leads to immediate dysfunction of the transplanted organ as well as induction of long-term rejection. The main hypothesis is that early treatment with complement system and toll-like receptor inhibitors will reduce short-term as well as long-term consequences of reperfusion injury. We will thus aim to identify (i) when to introduce treatment in the donation/transplantation process and (ii) which inhibitor has the greatest potential for transfer to clinical studies.

Current projects are:

  • Kidney transplant model using a living donor animal model and ex vivo normothermic machine perfusion (Oslo based collaborative project with the University of Aarhus, DK and University Medical Center Groningen, NL)
  • Systemic inflammation in brain death donors (Aarhus based collaborative animal project with the University of Aarhus, DK and University Medical Center Groningen, NL)
  • Complement and Toll-like receptor inhibition in brain death donors (Groningen based collaborative animal project at the University Medical Center Groningen, NL)
  • In vitro hypoxia/reoxygenation of endothelial cells (Oslo based)

Participants

Schjalm, Camilla Chief medical laboratory technologist
de Boer, Eline PhD student
Roscher, Elin PhD student
Mollnes, Tom Eirik Professor at University of Oslo
Pettersen, Kristin Medical laboratory technologist